2型糖尿病患者血脂水平与血清Apelin等细胞因子的关系研究

张爱鸣; 李锐; 厉钗微

doi:DOI   10.3784/j.issn.1003-9961.2009.12.020

2型糖尿病患者血脂水平与血清Apelin等细胞因子的关系研究

Relationship between serum apelin, adiponectin, resistin and blood lipid level in patients with type 2 diabetes

摘要

摘要: 目的了解2型糖尿病患者不同的血脂水平与血清、Apelin、脂联素、抵抗素等脂肪细胞因子的关系。方法所有的门诊或病房的2型糖尿病患者均空腹12 h以上,取肘静脉血, 分离血清，当日送检血脂及空腹血糖、胰岛素，其余血清置-80 ℃冰箱保存以备测定血清Apelin，脂联素及抵抗素。记录入选对象的年龄、糖尿病病程、身高、体重，通过公式计算BMI(体质指数)=体重/身高2(kg/m2),FPG(空腹血糖)及FINS(空腹胰岛素)并计算胰岛素抵抗指数（HOMA-IR）=(FPGFINS/22.5)。然后根据化验结果将患者分为2组。伴有高脂血症组,与血脂正常组。其中高脂血症组再分为：高甘油三酯组,高胆固醇组及混合组(2个指标均高于正常)，然后进行血脂与各组脂肪因子以及胰岛素抵抗指数的相关分析。结果两组患者，不同血脂水平之间的脂肪细胞因子差异有统计学意义。糖尿病患者血清Apelin水平与TG(甘油三酯)、FFA(游离脂肪酸)、BMI、FINS 呈显著正相关（分别R=0.766;R=0.675; R=0.780;R=0.821），P值均＜0.05，而与TC(胆固醇)、HDL-C(高密度脂蛋白)、LDL-C(低密度脂蛋白)无相关性。结论 2型糖尿病患者中伴有脂代谢紊乱者，血清Apelin水平明显升高且与患者的甘油三酯，游离脂肪酸的浓度密切相关，呈明显正相关。升高的Apelin水平可能参与与胰岛素抵抗的发生，其具体机制尚不明确,需进一步研究。

Abstract: Objective To investigate the relationship between serum apelin, adiponectin, resistin and blood lipid level in patients with type 2 diabetes.Methods Seventy-nine patients with type 2 diabetes were recruited and divided into 4 groups according to the lipid levels: A: normal lipid metabolism group, B: hypertriglycridemia group; C: hypercholesterolemic group, D: B and C group.The serum apelin levels was determined with competitive ELISA, the apelin levels of 4 groups were compared.The body mass index (BMI), fasting plasma glucose (FPG), fasting insulin levels were also measured.Results The serum apelin level in type 2 diabetes with hypertriglycridemia was significantly higher than normal lipid metabolism group.Correlation analysis showed that the serum apelin level in type 2 diabetes was positively correlated with TG (R=0.766), FFA (R=0.675)，BMI（R=0.780），FINS（R=0.821）.ConclusionSerum apelin levels in type 2 diabetes patients with lipid metabolism disorder increased.Apelin is correlated with TG, FFA, BMI and FINS.

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